CycleGuardian: a framework for automatic respiratory sound classification based on improved deep clustering and contrastive learning

Abstract Auscultation plays a pivotal role in early respiratory and pulmonary disease diagnosis.Despite the emergence of deep learning-based methods for automatic respiratory sound classification post-Covid-19, limited datasets impede performance enhancement.Distinguishing between normal and abnormal respiratory sounds poses challenges due to the c

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Subclass and avidity of circumsporozoite protein specific antibodies associate with protection status against malaria infection

Abstract RTS,S/AS01 is an advanced pre-erythrocytic malaria vaccine candidate with demonstrated vaccine efficacy up to 86.7% in controlled human malaria infection (CHMI) studies; however, reproducible immune correlates of protection (CoP) are elusive.To identify candidates of humoral correlates of vaccine mediated protection, we measured antibody m

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Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question

With FDA-approved devices, left atrial appendage (LAA) occlusion has emerged as a well-established and rapidly growing approach to stroke prevention in patients with non-valvular atrial fibrillation.These devices are indicated for use in patients who are at increased risk of stroke and systemic embolism, as determined by CHA2DS2-VASc scores, and ar

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